Polynucleotides vs. Profhilo: What’s the Difference and Which One is Right for You?

One of the most common questions I get asked is: “What’s the difference between polynucleotides and Profhilo? Why would I choose one over the other?”

Both treatments fall under the category of skin boosters, meaning they focus on improving skin quality, hydration, and overall skin health. However, while they share some similarities, they work in different ways and are suited to different concerns.

Let’s break it down.

What is Profhilo?

Profhilo is an injectable skin booster made from hyaluronic acid (HA). It’s fantastic for deep hydration, improving skin firmness, and stimulating collagen production. Since its launch, it has become a go-to treatment for skin rejuvenation, and if you haven’t heard of it yet, you may have been living under a rock!

What Profhilo Is Best For:

✔ Hydrating and plumping dry or crepey skin
✔ Improving skin laxity (particularly in the lower face, neck, and hands)
✔ Quick, minimal-downtime treatments (just five injection points per side)

Where Profhilo Works Best:

✅ Face (particularly lower face and jawline)
✅ Neck
✅ Hands

However, Profhilo isn’t ideal for delicate areas like under the eyes, as hyaluronic acid in this area can lead to prolonged swelling.

What Are Polynucleotides?

Polynucleotides are injectables derived from salmon or trout DNA fragments. They focus on repairing and regenerating the skin rather than just hydrating it. Polynucleotides help:

✔ Reduce oxidative stress and inflammation
✔ Improve skin elasticity and texture
✔ Promote deep tissue regeneration

What Polynucleotides Are Best For:

✔ Treating dark circles and fine lines under the eyes
✔ Targeting fine lines around the mouth (popular for postmenopausal women)
✔ Rejuvenating the neck and forehead

Unlike Profhilo, polynucleotides can be concentrated in specific areas, making them ideal for more targeted concerns.

How Many Treatments Do You Need?

⏳ Profhilo:
➡ Two sessions, one month apart, with results lasting 4-6 months
➡ Ideal for quick skin refreshes (popular among brides and event-prep clients)

⏳ Polynucleotides:
➡ Three to four sessions, spaced a couple of weeks apart, with results improving over time
➡ Can last 4-6 months, with maintenance as needed

Which One is Better?

There’s no “better” option—only what’s best for your skin and goals. It depends on:

✔ Your primary concern (hydration vs. regeneration)
✔ The area being treated
✔ Your treatment timeline (long-term skin health vs. an upcoming event)

Personally, I love polynucleotides under my eyes for a fresher, more awake look, and I use Profhilo on my face when I need a quick skin boost. The best treatment is the one that fits your unique needs.

💉 Want to know which is right for you? Book a consultation with our award-winning team today—we’ll create a personalised treatment plan for glowing, youthful skin!